Figure 1.

T cell responses against an HCV genotype-3 overlapping peptide set in HCV genotype-3 infected patients. HCV genotype-3 specific T cell responses were measured by IFNγ-ELISpot assays (SFU/10⁶ PBMCs) using an HCV genotype-3-specific peptide set spanning the entire HCV genome. T cell responses over cut-off were detected in (A) 16/16 individuals with spontaneously resolved infection and 3/4 patients with acute infection that subsequently spontaneously resolved infection (acutely infected→SR); (B) 6/12 patients with acute HCV genotype-3 infection that did not clear infection; and (C) 56/108 individuals chronically infected with HCV genotype-3. (D) Comparison of total magnitude of T cell response in IFNγ-ELISpot assays to HCV structural and non-structural viral regions is depicted. SFU, spot forming units; NS3p NS3 protease; NS3h NS3 helicase; NS5BI proximal NS5B region; NS5BII distal NS5B region; ns, not significant; PBMC, peripheral blood mononuclear cell; SR, spontaneously resolved patients; C, chronic; uk, unknown; SVR, sustained virological response; NR, non-responder. P values are given between patient groups.