Table 2.
Synovial tissue volume and pain: baseline and follow-up visits
| Baseline visit | Follow-up visit | Difference* | Difference; non-responders† | Difference; responders† | ||
|---|---|---|---|---|---|---|
| Variable | Mean (SD) | Mean (SD) | Mean (95% CI) | p Value | Mean (95% CI) | Mean (95% CI) |
| Synovitis volume (mm3) | 9935 (6470) | 8864 (7802) | −1071 (−1839 to −303) | 0.01 | −159 (−1553 to 1235) | −1474 (−2401 to −548) |
| Synovial fluid volume (mm3) | 9872 (6852) | 9019 (7449) | −853 (−1615 to −90) | 0.03 | −416 (−1797 to 964) | −1045 (−1962 to −128) |
| KOOS pain subscale score‡ (0–100) | 45.6 (14.6) | 69.5 (19.8) | 23.9 (20.1 to 27.8) | <0.001 | 0.5 (−4.6 to 5.5) | 33.6 (30.4 to 36.8) |
| Pain on Nominated Activity VAS (0–10) | 6.53 (1.8) | 3.30 (2.7) | −3.23 (−3.8 to −2.7) | <0.001 | −0.7 (−1.5 to 0.2) | −4.2 (−4.8 to −3.7) |
*Within-person difference between baseline and follow-up visit.
†Responders are those who satisfied OARSI response criteria.
‡Lower KOOS scores denote worse pain.
KOOS, Knee Injury and Osteoarthritis Outcome Score; VAS, Visual Analogue Scale.