Table 3.
Synovial tissue volume and pain: baseline, follow-up and final visits, split by response type
| Variable | Baseline, mean (SD) | Follow-up, mean (SD) | Final Visit, mean (SD) | Difference; Baseline to follow-up Visit | Difference; Follow-up to final Visit |
|---|---|---|---|---|---|
| Mean (95% CI) | Mean (95% CI) | ||||
| (A) Initial responders, whose pain recurred within 6 months (‘Relapsers’) | |||||
| Synovitis volume (mm3) | 10 319 (5419) | 8609 (5517) | 9829 (5048) | −1710 (−2904 to −515) | 1220 (25 to 2414) |
| Synovial fluid volume (mm3) | 10 023 (5408) | 8690 (5514) | 9860 (5152) | −1334 (−2555 to −113) | 1170 (−51 to 2391) |
| KOOS pain subscale score (0–100) | 45.1 (13.6) | 75.57 (14.7) | 47.89 (17.1) | 30.42 (26.1 to 34.7) | −27.7 (−32.0 to −23.4) |
| Pain on nominated activity VAS (0–10) | 6.5 (1.5) | 1.99 (1.8) | 6.41 (2.3) | −4.5 (−5.2 to −3.8) | 4.4 (3.7 to 5.1) |
| (B) Initial responders, whose pain did not recur within 6 months (‘Persistent responders’) | |||||
| Synovitis volume (mm3) | 8627 (5308) | 7782 (4436) | 7580 (5401) | −845 (−2651 to 961) | −202 (−2008 to 1604) |
| Synovial fluid volume (mm3) | 8676 (5602) | 8322 (5407) | 7663 (5323) | −355 (−2201 to 1491) | −658 (−2504 to 1188) |
| KOOS pain subscale score (0–100) | 42.9 (15.9) | 83.9 (12.5) | 73.3 (17.7) | 41.0 (34.3 to 47.8) | −10.6 (−17.3 to −3.9) |
| Pain on nominated activity VAS (0–10) | 6.5 (1.6) | 2.4 (2.2) | 3.6 (2.5) | −4.1 (−5.2 to −3.0) | 1.3 (0.2 to 2.4) |
KOOS, Knee Injury and Osteoarthritis Outcome Score; VAS, Visual Analogue Scale.