Table 4.

Commonly used antihypertensive plants with anti-proliferative activity.

Herb	Effect	Concentration/Dose	Experimental setting/Model	References
Allium sativum	Induces Cx43 expression	50 μM	Sprague-Dawley rat thoracic aortic VSMCs	Joshi et al., 2012
	Inhibits Ang-II-induced cell cycle progression	100 μM (two of its components)	VSMCs isolated from SHR	Castro et al., 2010
Camellia sinensis	Increases HO-1 enzyme	0–50 μM	Human aortic smooth muscle cells	Liu et al., 2014
Coptis chinensis	Inhibits cardiac hypertrophy	300 mg/kg	Rat isolated cardiomyocytes (insulin-induced hypertrophy)	Zhang et al., 2011
Panax	Inhibits ERK pathway activation	10% of plasma isolated from rats injected with 200 mg/kg of the extract	PDGF-treated rat VSMCs	Zhang et al., 2012
	Decreases CDK4, pRb, and cyclin D1	20–40 mg/ml	SHR thoracic aortic VSMCs	Tao and Lei, 2012
	Decreases β-galactosidase	20–40 mg/ml	SHR and WKY rat thoracic aortic VSMCs	Tao and Lei, 2012
Salviae miltiorrhizae	Inhibits PDGF proliferation	100 μg/ml	Sprague-Dawley rat thoracic aortic VSMCs	Cho et al., 2013