| Study | Reason for exclusion |
|---|---|
| Aderka 1986 | A non‐randomised retrospective study |
| Agliastro 2006 | Comparison of apheresis versus buffy coat platelet transfusions ( abstract) |
| Akkök 2007 | Comparison of apheresis versus buffy coat platelet transfusions |
| Anderson 1997 | Comparison of apheresis versus buffy coat ‐derived versus platelet rich plasma ‐derived platelet products |
| Andreu 2009 | Review |
| Andrew 1993 | Wrong patient group ‐ premature infants |
| Arnold 2004 | Comparison of apheresis versus whole blood ‐derived platelet transfusions |
| Arnold 2006 | Wrong patient group ‐ intensive treatment unit |
| Avvisati 2003 | Review |
| Bai 2004 | Wrong patient group ‐ solid tumours |
| Benjamin 2002 | Review |
| Bentley 2000 | Comparison of autologous versus allogeneic platelet transfusions |
| Blajchman 2008 | Review |
| Blumberg 2002 | Comparison of washed versus standard platelet transfusions |
| Blumberg 2004 | Comparison of washed versus standard platelet transfusions |
| Blundell 1996 | Comparison of standard versus pathogen inactivated platelets |
| Buhrkuhl 2010 | Review |
| Callow 2002 | A non‐randomised prospective study with historical control |
| Cameron 2007 | A non‐randomised prospective study |
| Carr 1990 | Comparison of ABO‐matched versus mismatched platelet products |
| Casbard 2004 | Systematic review and wrong patient group |
| Chaoui 2005 | Observational prospective study |
| Chaurasia 2012 | A non‐randomised prospective study |
| Cid 2007 | Systematic review of differing platelet transfusion doses |
| Corash 2001 | Comparison of intercept platelet components versus standard platelet components |
| Couban 2002 | Comparison of plasma reduction and leucodepletion |
| de Wildt‐Eggen 2000 | Comparison of platelet concentrates in plasma versus additive solution |
| Decaudin 2004 | Non‐randomised prospective study |
| Di Pietro 1998 | Comparison of HLA ‐matched versus random ‐donor apheresis platelet components |
| Diedrich 2009 | Comparison of platelet products stored 1 ‐ 5 versus 6 ‐ 7 days |
| Dumont 2011 | Comparison of buffy coat versus platelet rich plasma platelet concentrates |
| Dzik 2004 | Review |
| Eder 2007 | Non‐randomised observational study |
| Elting 2002 | Retrospective analysis ‐ lymphoma and solid tumours |
| Elting 2003 | Non‐randomised retrospective cohort ‐ lymphoma and solid tumours |
| Fanning 1995 | Wrong patient group ‐ gynaecological cancer |
| Follea 2004 | Guideline |
| Friedmann 2002 | A non‐randomised retrospective analysis |
| Gajic 2006 | Wrong patient group ‐ intensive treatment unit |
| Gerday 2009 | Wrong patient group ‐ neonates |
| Gil‐Fernandez 1996 | A non‐randomised retrospective historical control study (different platelet transfusion thresholds) |
| Gmür 1983 | Comparison of single ‐donor versus pooled platelet products |
| Gmür 1991 | A non‐randomised prospective cohort observational study (different platelet transfusion thresholds) |
| Goodnough 2001 | Fewer than 80% of participants diagnosed with a haematological disorder ‐ different platelet doses |
| Goodnough 2002 | Review |
| Goodnough 2005 | Review |
| Goodrich 2008 | Comparison of pathogen inactivated versus standard apheresis platelets |
| Greeno 2007 | A non‐randomised prospective observational study (different platelet transfusion thresholds) |
| Grossman 1980 | Comparison of prophylactic versus therapeutic platelet transfusions |
| Gurkan 2007 | Comparison of apheresis versus pooled platelet products |
| Hardan 1994 | A non‐randomised observational study, therapeutic platelets only, historical control reported only as an abstract |
| Harrup 1999 | Comparison of buffy coat plasma versus T‐sol platelet transfusions |
| Heal 1993 | Comparison of ABO ‐compatible versus mismatched platelet transfusions |
| Heal 2004 | Review |
| Heddle 1994 | Comparison of plasma from platelet concentrates versus platelets |
| Heddle 1999 | Comparison of plasma removal versus leucodepletion |
| Heddle 2002 | Comparison of plasma removal versus leucodepletion |
| Heddle 2003 | Systematic review ‐ methods of assessing bleeding outcome |
| Heddle 2005 | Comparison of whole blood ‐derived platelets stored as a pool versus individually |
| Heddle 2007 | Review |
| Heddle 2009 | Comparison of a low dose versus standard platelet component dose |
| Higby 1974 | Comparison of prophylactic platelets versus platelet poor plasma |
| ISRCTN01292427 | Comparison of dynamic light scattering‐screened versus unscreened platelets |
| ISRCTN49080246 | Comparison of 1 ‐ 5 versus 6 ‐ 7 day ‐old platelet transfusions |
| ISRCTN56366401 | Comparison of different types of platelet component |
| Jelic 2006 | Review |
| Johansson 2007 | Wrong patient group ‐ ruptured abdominal aortic aneurysm |
| Julmy 2009 | Wrong patient group ‐ ruptured abdominal aortic aneurysm |
| Kakaiya 1981 | Comparison of apheresis versus pooled platelet concentrates |
| Kerkhoffs 2010 | Comparison of standard platelets versus pathogen inactivated platelets versus platelets stored in PAS II media |
| Klumpp 1999 | A randomised cross‐over study. This study was included within the previous systematic review ; however, due to stricter inclusion/exclusion criteria, this study has now been excluded from the review. Only laboratory outcomes were reported. 37% of participants had a non‐haematological malignancy (breast cancer) |
| Kluter 1996 | Comparison of random ‐donor platelet components from pooled buffy coats versus apheresis platelet components |
| Lapierre 2003 | Comparison of standard apheresis platelet products versus a donor reduction policy |
| Lawrence 2001 | A non‐randomised retrospective historical control study (different platelet transfusion thresholds) |
| Leach 1991 | Comparison of warmed versus standard platelet transfusions |
| Lee 1989 | Comparison of ABO ‐matched versus mismatched platelet transfusions |
| Levi 2002 | Review |
| Lordkipanidze 2009 | Review |
| Lozano 2003 | Review |
| Lozano 2010 | Efficacy of older platelet transfusions |
| Lozano 2011 | Comparison of pathogen inactivated versus conventional platelet products |
| Lu 2011 | Comparison of a low ‐dose versus standard ‐dose platelet component |
| Martel 2004 | Review |
| McCullough 2004 | Comparison of pathogen inactivated versus conventional apheresis platelets |
| McNicol 2003 | Review |
| Messerschmidt 1988 | Comparison of HLA ‐matched versus mismatched platelet transfusions |
| Mirasol 2010 | Comparison of pathogen inactivated versus conventional platelet products |
| Murphy 1982 | Comparison of a prophylactic versus therapeutic platelet transfusion policy |
| Murphy 1986 | Comparison of HLA ‐matched and leucodepleted blood products |
| Navarro 1998 | A non‐randomised retrospective historical control observational study (different platelet transfusion thresholds) |
| NCT00699621 | Wrong patient group ‐ intracerebral haemorrhage |
| NCT01615146 | Comparison of a prophylactic versus therapeutic platelet transfusion policy |
| Nevo 2007 | A non‐randomised retrospective analysis (different platelet thresholds) |
| Norol 1998 | A non‐randomised prospective comparison ( 3 different doses of platelets) |
| Norville 1994 | Comparison of 2 different infusion pumps for platelet transfusions |
| Norville 1997 | Comparison of 2 different infusion rates |
| Oksanen 1991 | Comparison of pre‐ versus poststorage leucodepletion of p latelet rich plasma ‐derived platelet transfusions |
| Oksanen 1994 | Comparison of leucodepleted buffy coat ‐derived platelet transfusions versus historical control |
| Paananen 2009 | Non‐randomised study (unclear whether prospective or retrospective) |
| Pamphilon 1996 | Comparison of buffy coat platelet components, single ‐donor apheresis non‐leucocyte depleted and single ‐donor apheresis leucocyte‐depleted platelet components |
| Paramo 2004 | Review |
| Poon 2003 | Review |
| Qureshi 2007 | Audit of platelet transfusions in the United Kingdom |
| Rabinowitz 2010 | Review |
| Rayment 2005 | Review |
| Razzaghi 2012 | Systematic review of platelet transfusion threshold in people with gastrointestinal bleeding |
| Rebulla 2009 | Comparison of pathogen inactivated versus standard platelet components |
| Reed 1986 | Wrong patient group ‐ massive transfusion |
| Roberts 2003 | Review |
| Roy 1973 | Comparison of different platelet component doses |
| Sagmeister 1999 | A non‐randomised retrospective study (aplastic anaemia) |
| Sakakura 2003 | Review |
| Samama 2005 | Guideline |
| Schiffer 1983 | Comparison of leucodepleted versus standard platelet concentrates |
| Sensebe 2004 | Comparison of different platelet component doses |
| Shanwell 1992 | Comparison of fresh versus stored platelets |
| Shehata 2009 | Systematic review ‐ ABO ‐identical versus non‐identical platelet transfusions |
| Shen 2007 | Review |
| Singer 1988 | Single ‐donor HLA ‐matched versus random ‐donor platelets |
| Sintnicolaas 1981 | Comparison of single ‐donor and multiple ‐donor platelet components |
| Sintnicolaas 1982 | Comparison of a prophylactic versus therapeutic platelet transfusion policy |
| Sintnicolaas 1995 | Comparison of leucocyte depleted versus standard platelets |
| Slichter 1998 | Comparison of apheresis versus pooled platelet components |
| Slichter 2004 | Review |
| Slichter 2006 | Comparison of pathogen inactivated versus conventional apheresis platelets |
| Slichter 2007 | Review |
| Slichter 2010 | Comparison of different platelet component doses |
| Slichter 2012 | Review |
| Solomon 1978 | Comparison of a prophylactic versus therapeutic platelet transfusion policy |
| Sosa 2003 | Review |
| Spiess 2004 | Wrong patient group ‐ cardiac |
| Stanworth 2013 | Comparison of a prophylactic versus therapeutic platelet transfusion policy |
| Steffens 2002 | Comparison of different platelet component doses |
| Strauss 2004 | Review |
| Strauss 2005 | Review |
| Strindberg 1996 | Comparison of apheresis versus buffy coat platelet products |
| Sweeney 2000 | Comparison of pre‐storage leucodepleted versus bedside leucodepleted platelets |
| Tinmouth 2003 | Review |
| Tinmouth 2004 | Comparison of low ‐dose platelet components versus standard ‐dose platelet components |
| Tosetto 2009 | Guideline |
| TRAP 1997 | Comparison of standard pooled platelet product versus irradiated pooled platelet product versus leucodepleted pooled platelet product versus apheresis platelet product |
| Vadhan‐Raj 2002 | Wrong patient group ‐ gynaecological malignancy |
| Van Marwijk 1991 | Comparison of leucodepleted platelet products prepared by filtration or centrifugation |
| van Rhenen 2003 | Comparison of pathogen inactivated versus standard buffy coat ‐derived platelet transfusions |
| Velik‐Salchner 2007 | Non‐human study |
| Verma 2008 | A non‐randomised observational study |
| Wandt 1998 | A non‐randomised prospective cohort study (not randomised at the participant level) |
| Wandt 2005 | A non‐randomised prospective study with an historical case control (therapeutic versus prophylactic platelet transfusions) |
| Wandt 2006 | A non‐randomised prospective study with an historical case control (therapeutic versus prophylactic platelet transfusions) |
| Wandt 2010 | Review |
| Wandt 2012 | Comparison of a prophylactic versus therapeutic platelet transfusion policy |
| Wang 2002 | A comparison of acetaminophen and diphenhydramine versus placebo as premedication for platelet transfusions |
| Wang 2005 | Review |
| Weigand 2009 | Prospective observational study |
| Williamson 1994 | Comparison of standard versus bedside leucodepleted platelet products |
| Woodard 2002 | Review |
| Zahur 2002 | Prospective observational study |
| Zeller 2014 | Review |
| Zhao 2002 | Comparison of leucodepleted versus standard platelet transfusions |
| Zumberg 2002 | This study was included within the previous systematic review ; however, due to stricter inclusion/exclusion criteria, this study has now been excluded from the review. 31% of participants had a non‐haematological malignancy (breast cancer) |
HLA = human leukocyte antigen