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. 2016 Jan 19;23:5. doi: 10.1186/s12929-016-0231-x

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© Huang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Omentum-derived ASC transplantation attenuated APAP-induced inflammation, and MAPK signaling activation. Omentum-derived ASC transplantation decreased the expression of the pro-inflammatory cytokines (a) IL-1α and (b) IL-1β and increased the expression of anti-inflammatory cytokines (c) IL-6 and (d) IL-10 to a significant degree. Omentum-derived ASC transplantation suppressed the MAPK signaling pathway activation induced by APAP treatment. e Liver tissue was collected 6 h after omentum-derived ASC transplantation into APAP-treated mice and used for RT-PCR (a, b, c and d) and western blot (e) analysis. (f) CYP 450 2E1, CYP 450 1A2, NTR, and 4-HNE protein expression by western blot analysis. (g) CYP2A5 gene expression by RT-PCR. The data are expressed as the means ± SEM, n ≥ 5, **P < 0.01, ***P < 0.001