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. 2016 Jan 19;13:13. doi: 10.1186/s12974-015-0407-4

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© Esen et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — CD4+ T cells were less in the hypoxic EAE spinal cords at day 14. Immune cells were recovered from mice (three animals/group/time point) at days 7 and 14 following MOG immunization as described in the “Materials and methods” and analyzed by FACS. Gating was done first on the CD11b-CD45hi cells and then further plotted for CD3, CD4, and CD25 expressions (a). Total numbers of CD3+CD4+ (b) and CD4+CD25+ (c) cells in the spinal cords were presented (mean ± SD). A representative dot plot of CD4+CD25+FoxP3+ (d) and the absolute numbers (e) are presented (mean ± SD). Significant differences between hypoxia-exposed and normoxic EAE mice are denoted with pound sign (^# p < 0.05)