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. 2016 Jan 19;18:9. doi: 10.1186/s13058-015-0668-y

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© Wang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Analysis of mutant p53 accumulation in tumor cells. a-c p53 IHC of WAP-Cre:Pten^fl/fl:p53^R270H/wt tumors showing lack of p53 accumulation, indicating the p53^R270H allele was not activated in (a). Arrows and dashed outlines indicate a region with strong p53 accumulation; arrowheads and dotted outlines to regions with weak or no p53 accumulation (b). Note strong nuclear accumulation of mutant p53 in tumor cells (c). d Summary of mutant p53 accumulation in the major tumor types in WAP-Cre:Pten^fl/fl:p53^R270H/wt mice: mixed, n = 9; squamous, n = 4; AME, n = 9; spindle, n = 12; PDA, n = 6. AME adenomyoepithelioma, IHC immmunohistochemistry, PDA poorly differentiated adenocarcinoma