Table 4.
Association of SNPs with clinical and malariometric indices
| SNP (gene) | Alleles | Comparison | Parasite density | Hb (g/dL) | Spleen Size | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fulani | Dogon | Fulani + Dogon | Fulani | Dogon | Fulani + Dogon | Fulani | Dogon | Fulani + Dogon | |||||||
| Normal | Enlarged | Normal | Enlarged | Normal | Enlarged | ||||||||||
| FCγRIIB (rs1050519) | Ref | G | GG vs TT/GT | 100 | 1,030 | 665 | 8.75 | 9.6 | 9.3 | 56 | 65.63 | 78.69 | 75 | 74.8 | 71.59 |
| Alt | T | 129.5 | 803.5 | 375 | 8.4 | 9.2 | 9.05 | 44 | 34.38 | 21.31 | 25 | 25.17 | 28.41 | ||
| p Value | 0.309 | 0.795 | 0.285 | 0.382 | 0.6 | 0.821 | 0.585 | 0.569 | 0.647 | ||||||
| FCγRIIC (rs3933769) | Ref | C | CC vs TT/CT | 80 | 1,120 | 970 | 9.9 | 9.4 | 9.5 | 24 | 25 | 63.93 | 62.50 | 57.14 | 48.86 |
| Alt | T | 140 | 709 | 386.5 | 8.5 | 9.65 | 8.95 | 76 | 75 | 36.07 | 37.50 | 42.86 | 51.14 | ||
| p value | 0.235 | 0.064 | 0.00001* | 0.125 | 0.559 | 0.357 | 1.000 | 0.868 | 0.227 | ||||||
| FCγRIIIA (rs36991) | Ref | A | AA vs GG/AG | 145.5 | 1000 | 675 | 8.7 | 9.5 | 9.2 | 72 | 62.5 | 58.2 | 66.07 | 60.54 | 64.77 |
| Alt | G | 90 | 1000 | 511.5 | 8.5 | 9.5 | 9.3 | 28 | 37.5 | 41.8 | 33.93 | 39.46 | 35.23 | ||
| p value | 0.379 | 0.325 | 0.361 | 0.696 | 0.691 | 0.834 | 0.574 | 0.409 | 0.579 | ||||||
Comparison of parasite density, Hb levels and spleen size in participants with wild and mutant alleles
Comparisons were done in the two tribes separately and in the entire study
* Statistically significant differences (p < 0.05)