Table 5.
Association of SNPs with antibody levels
| SNP (gene) | Alleles | Comparison | Antibody responses (Mean Log 10) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fulani | Dogon | Fulani + Dogon | ||||||||||
| IgG | IgG1 | IgG3 | IgG | IgG1 | IgG3 | IgG | IgG1 | IgG3 | ||||
| (FcγRIIB (rs1050519) | Ref | G | GG vs TT/GT | 9.267 | 29.79 | 0.429 | 5.49 | 8.897 | 0.33 | 5.76 | 10.39 | 0.3475 |
| Alt | T | 10.86 | 37.08 | 0.30 | 3.95 | 11.90 | 0.34 | 5.16 | 14.03 | 0.33 | ||
| p Value | 0.795 | 0.908 | 0.105 | 0.301 | 0.317 | 0.755 | 0.956 | 0.251 | 0.439 | |||
| FCγRIIC (rs3933769) | Ref | C | CC vs TT/CT | 14.61 | 44.31 | 0.33 | 5.35 | 10.21 | 0.35 | 5.71 | 11.31 | 0.34 |
| Alt | T | 7.74 | 28.76 | 0.35 | 4.63 | 7.35 | 0.33 | 5.81 | 10.45 | 0.34 | ||
| p Value | 0.367 | 0.392 | 0.594 | 0.311 | 0.706 | 0.790 | 0.872 | 0.670 | 0.933 | |||
| FCγRIIIA (rs36991) | Ref | A | AA vs GG/AG | 9.83 | 12.27 | 0.35 | 5.09 | 6.66 | 0.32 | 5.74 | 8.31 | 0.34 |
| Alt | G | 11.29 | 54 | 0.32 | 5.33 | 13.06 | 0.35 | 5.94 | 18.56 | 0.35 | ||
| p Value | 0.898 | 0.127 | 0.314 | 0.839 | 0.082 | 0.015* | 0.712 | 0.023* | 0.158 | |||
Comparison of antibody levels in participates with wild and mutant alleles
Comparisons were done in the two tribes separately and in the entire study
* Statistically significant differences (p < 0.05)