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. 2015 Dec 1;9(12):ZE05–ZE07. doi: 10.7860/JCDR/2015/16670.6918

[Table/Fig-1]:

Major enzymes of leech saliva and their functions [7]

Enzymes /substances Function
1. Hirudin The most well known enzyme, a powerful anticoagulant in existence, than heparin
2. Bdellin A protease inhibitor thus acts as anti-inflammatory.
3. Apyrase A powerful platelet anti-aggregate factor thus making blood flow more fluid.
4. Eglin It is also an inhibitor of inflammation but at the same time it is an anti-oxidant.
5. Destabilase The enzyme has very powerful platelet anti-aggregating activity which acts by dissolving the blood clots, thus opening up very exciting therapeutic avenues.
6. Hyaluronidase It acts both as factor for diffusion and as an antibiotic.
7. Lipase and Esterase Used for hyperlipidaemia.
8. Anti-elastase This substance acts by limiting the action of Elastases which degrade cutanous elastin particularly at the level of skin.