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. 2015 Oct 29;20(1):116–127. doi: 10.1111/jcmm.12709

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© 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Evaluation of the pressure overload‐induced CH rat model. Four weeks after AAC surgery, CH was evaluated by measuring BP, cardiac function and HW/BW, HW/TL, and LV mass. Occlusion and volume‐pressure recording cuffs were placed over their tails to measure blood pressure, including SP (A), DP (B), and MP (C), by tail‐cuff manometry. Additionally, cardiac function including EF% (D) and FS% (E) and LV mass (F) were investigated by echocardiographic analysis. After the rats were killed, the hearts were removed and weighed followed by calculating the HW/BW (G) and HW/TL (H). Data are presented as means ± S.D., n = 8 in each group. *P < 0.05 versus the SO group. HW: heart weight; BW: body weight; TL: tibia length.