Table 2.
Worldwide reports of the NDM cases
| Genotyping | Related diseases | Antibiotic therapy | Clinical outcomes | Reference |
|---|---|---|---|---|
| NDM-1 | Recurrent pyelonephritis | ATM, CL | Fever and abdominal pain resolved within 48 h after administration of antibiotics | [36] |
| NDM-1 | Periappendicular abscess | CIP, MTZ, TZP | Good clinical response | [69] |
| NDM-1 | Crush trauma | CIP, CC, MEN, VA, CL, TGC | He finally succumbed from refractory circulatory shock* | [71] |
| NDM-1 | Persistent nonbloody diarrhea unspecified encephalitis | IMP, VA, MTZ, CL, CHL | Her condition worsened and she died† | [38] |
| NDM-3 | Community-acquired uncomplicated cystitis | F/M | Resolve all clinical symptoms | [4] |
| NDM-1 | Calciphylaxis | TZP, TGC, CIP, CL, MEM and TEC | Six months after initial presentation, the patient remains clinically stable | [58] |
| NDM-1 | Extensive electrical burns | MEM, cotrimoxazole, CL, TEC | His fever defervesced, blood cultures became sterile. His wounds had healed and no MDR were detected | [8] |
*The critically ill patient got acute respiratory muscle weakness and apnea that were induced by colistin neurotoxicity; †The final diagnosis of this patient was toxic metabolic leukoencephalopathy, probably related to sepsis. TEC: Teicoplanin; TGC: Tigecycline; MEN: Meropenem; CIP: Ciprofloxacin; VA: Vancomycin; TZP: Piperacillin/tazobactam; ATM: Aztreonam; CL: Colistin; MTZ: Metronidazole; CHL: Chloramphenicol; F/M: Nitrofurantoin; CC: Clindamycin; IMP: Imipenem; Co-trimoxazole: Trimethoprim-sulfamethoxazole; NDM: New Delhi metallo-β-lactamase.