Table 2.

Treatment-related adverse effects according to treatment group and Common Toxicity Criteria scale version 3.0

Adverse events	Grades 1–2, n (%)			Grades 3–4, n (%)
	GTC (n = 32)	SC (n = 75)	P	GTC (n = 32)	SC (n = 75)	P
Fever	23 (71.9)	19 (25.3)	0.001†	2 (6.3)	3 (4.0)	0.634
Fatigue	18 (56.2)	39 (52.0)	0.687	3 (9.4)	3 (4.0)	0.517
Hand-foot skin reaction	11 (34.4)	27 (36.0)	0.872	0	0	–
Nausea	21 (65.6)	43 (57.3)	0.423	3 (9.4)	5 (6.7)	0.694
Vomiting	18 (56.3)	37 (49.3)	0.512	1 (3.1)	3 (4.0)	0.735
Diarrhea	13 (40.6)	21 (28.0)	0.199	0	0	–
Abdominal pain	23 (71.9)	9 (12.0)	0.001	7 (21.9)	1 (1.3)	0.001†
Anemia	14 (43.8)	24 (32.0)	0.245	3 (9.4)	5 (6.7)	0.694
Neutropenia	11 (34.4)	25 (33.3)	0.916	2 (6.3)	6 (8.0)	0.931
Bilirubin abnormality	19 (59.2)	9 (12.0)	0.001†	3 (9.4)	0	0.025*
Alanine transaminase abnormality	20 (62.5)	11 (14.7)	0.001†	5 (15.6)	2 (2.7)	0.040*

*P<0.05; ^†P<0.001. –: Not applicable; GTC: Gastrectomy, TACE, Chemotherapy; SC: Systemic chemotherapy.