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. 2015 Aug 20;128(16):2220–2227. doi: 10.4103/0366-6999.162507

Figure 2.

Figure 2

Impaired memory function in 5XFAD mice shown by water maze testing (5XFAD mice, 3 months of age, n = 7, 6 months of age, n = 7, wild-type counterparts, 3 months of age, n = 7, 6 months of age, n = 7). (a): At 3 months, the latency was not significantly different between wild-type and 5XFAD mice. At 6 months, the latency of 6-month-old 5XFAD mice was significantly longer than that of 3-month-old 5XFAD mice (P = 0.0034) and of 6-month-old wild-type mice (*P = 0.0262); (b): At 6 months, the total times crossing the platform for 6-month-old 5XFAD mice was significantly reduced as compared with that for 6-month-old wild-type mice (*P = 0.0157) and 3-month-old 5XFAD mice (P = 0.0223), and no significant difference between two wild-type groups.