Figure 4.

Representative images of the 2-deoxy-2-(¹⁸F) fluoro-D-glucose brain uptake of a wild-type and 5XFAD transgenic mouse at 3 and 6 months (5XFAD mice, 3 months of age, n = 7, 6 months of age, n = 7, wild-type counterparts, 3 months of age, n = 7, 6 months of age, n = 7). At 3 months, no significant difference was found between 5XFAD and wild-type mice in the hippocampus and cerebral cortex; at 6 months, the uptake was remarkably reduced in both hippocampus (*P = 0.0121) and cerebral cortex (*P < 0.0001). In the olfactory bulb, the uptake of the 3-month-old 5XFAD mice was significantly lower than that of age-matched wild-type mice (*P = 0.023); and at 6 months, the uptake of the 5XFAD mice was much lower than that of age-matched wild-type mice (*P < 0.0001).