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. 2015 Nov 24;35(1):77–88. doi: 10.15252/embj.201592374

Figure 6. Computer simulations indicate that changes to homogeneous resting areas are able to alter cell topology.

Figure 6

  1. Diagram resulting from a vertex model simulation with homogeneous parameters for contractility, line tension and ideal area.
  2. Diagram resulting from a vertex model simulation where in ten percentage of the cells (grey), the line tension and ideal area parameters were reduced.
  3. Control diagram where in the ten percentage of the cells (blue) only line tension parameter was reduced.
  4. Comparison of polygon distribution for the 10% smallest cells from BCA (green bar) and control simulation (grey bar) with the sick cells from BNA (light blue bar) and atrophy simulation (grey cells from (B), purple bar).