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. 2016 Jan 6;18:2. doi: 10.1186/s13075-015-0903-z

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© Ma et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — NETs formation was dependent on NADPH oxidase in the presence of HMGB1 and ANCA-positive IgG. Blockage of NADPH oxidase decreased DNA release by MPO-ANCA-positive IgG (a) or PR3-ANCA-positive IgG (b) in HMGB1-pretreated cells. Blockage of NADPH oxidase decreased percentage of NETs formation by MPO-ANCA-positive IgG (c) or PR3-ANCA-positive IgG (d) in HMGB1-pretreated cells. Bars represent mean ± SD of repeated measurements on neutrophils of 13–14 independent experiments and 9 donors. ANCA antineutrophil cytoplasmic antibody, DPI diphenyleneiodonium, HMGB1 high-mobility group box 1, IgG immunoglobulin G, MPO myeloperoxidase, NETs neutrophil extracellular traps, PR3 proteinase 3