Table 4.

SNPs showing significant or borderline significant association in the cross-sectional analyses or in the GEE model

					Model 1			Model 2			GEE model
SNP	Chr	Position (bp)	Minor allele	MAF	Phenotype: ΔDAS-3			Phenotype: ΔDAS-6			Phenotype: ΔDAS-3 and ΔDAS-6
					N	β	P	N	β	P	N	β	P
rs284511	6	91,208,542	C	0.33	440	0.16	0.01	421	0.41	2.5×10−8	443	0.28	1.5×10−6
rs284515	6	91,208,828	G	0.17	438	0.35	5.6×10−5	419	0.36	1.1×10−4	443	0.35	6.6×10−7
rs75908454	6	169,970,623	C	0.10	440	0.36	0.0007	421	0.49	5.5×10−5	443	0.42	6.3×10−7
rs1679568	10	117,817,551	A	0.15	434	0.27	0.002	415	0.44	5.3×10−6	437	0.35	8.1×10−7

Association results from cross-sectional (models 1 and 2) and longitudinal (generalized estimating equations (GEE) model) analyses - for single nucleotide polymorphisms (SNPs) within regions showing borderline significant association with the GEE model. MAF minor allele frequency ΔDAS-3 and ΔDAS-6, change in Disease Activity Scores based on 28 joint counts (from baseline) at 3 months and 6 months, Chr chromosome