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. 2015 Jun 16;7(1):9–16. doi: 10.1111/1759-7714.12260

Figure 1.

figure

Forkhead box O (FOXO3) inhibits the expression of metastasis suppressor gene nm23‐H1 in in vitro experiments. (a) Western blot shows that the expression of nm23‐H1 decreased in the cells which were transfected with FOXO3‐WT, FOXO3‐TM plasmid, but increased with FOXO3‐δ‐DB. (b) and (c) Results show that in both A549 and A549‐99 cells, FOXO3‐TM decreased luciferase activity, while FOXO3‐δ‐DB significantly induced luciferase activity. (d) Results indicate that nm23‐H1 expression decreased after transfection with FOXO3‐TM, which increased with FOXO3‐δ‐DB.