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. 2015 May 19;7(1):50–60. doi: 10.1111/1759-7714.12274

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© 2015 The Authors. Thoracic Cancer published by China Lung Oncology Group and Wiley Publishing Asia Pty Ltd.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Expression of ΔE746–E750 deletion mutant epidermal growth factor receptor (EGFR) sensitizes cells to radiation. (a) Levels of ΔE746–E750 mutant EGFR protein expression in four cells. (B) expression of ΔE746–E750 deletion mutant EGFR decreased clonogenic survival after IR in A549‐del cells. Error bars, standard deviation (SD) from mean of triplicate measurements. (c) Radiation induced apoptosis was increased in radiosensitive mutant EGFR‐expressing A549‐del cells. Error bars, SD from mean of triple independent measurements. *P < 0.05. (d) A549‐del cells showed significantly more G2/M arrest and dismal S arrest compared with A549‐nc cells. Column, mean values of triple independent experiments. (b) () A549‐nc, () A549‐del, () H820; (c) () A549‐nc, () A549‐del, () H820; (d) () G1, () S, () G2. NC, negative control.

Inline graphic — Expression of ΔE746–E750 deletion mutant epidermal growth factor receptor (EGFR) sensitizes cells to radiation. (a) Levels of ΔE746–E750 mutant EGFR protein expression in four cells. (B) expression of ΔE746–E750 deletion mutant EGFR decreased clonogenic survival after IR in A549‐del cells. Error bars, standard deviation (SD) from mean of triplicate measurements. (c) Radiation induced apoptosis was increased in radiosensitive mutant EGFR‐expressing A549‐del cells. Error bars, SD from mean of triple independent measurements. *P < 0.05. (d) A549‐del cells showed significantly more G2/M arrest and dismal S arrest compared with A549‐nc cells. Column, mean values of triple independent experiments. (b) () A549‐nc, () A549‐del, () H820; (c) () A549‐nc, () A549‐del, () H820; (d) () G1, () S, () G2. NC, negative control.