Skip to main content
. Author manuscript; available in PMC: 2016 Jan 19.
Published in final edited form as: Lancet Oncol. 2009 Jul 1;10(8):764–771. doi: 10.1016/S1470-2045(09)70164-0

Figure 3. Suggested algorithm for molecular genetic testing for phaeochromocytoma and paraganglioma.

Figure 3

The presence of familial or clinical criteria for a phaeochromocytoma-associated or paraganglioma-associated inherited disease should lead to targeted genetic testing. In the absence of criteria, SDHB immunohistochemistry is indicated. A positive SDHB immunohistochemistry result should lead to VHL and RET genetic testing, a negative SDHB immunohistochemistry should lead to SDH (SDHD, SDHB, and SDHC) genetic testing, starting with SDHD in cases of head and neck paraganglioma or starting with SDHB in cases of thoracic–abdominal or pelvic paraganglioma.