| Nomenclature |
Interleukin‐1 receptor,
type I
|
Interleukin‐33
receptor
|
Interleukin‐36
receptor
|
Interleukin‐1 receptor,
type II
|
Interleukin‐18
receptor
|
| Subunits |
IL‐1 receptor accessory
protein (Other subunit), Interleukin 1 receptor,
type I (Ligand‐binding subunit) |
IL‐1 receptor accessory
protein (Other subunit), Interleukin‐1 receptor‐like
1 (Ligand‐binding subunit) |
IL‐1 receptor accessory
protein (Other subunit), Interleukin‐1 receptor‐like
2 (Ligand‐binding subunit) |
IL‐1 receptor accessory
protein (Other subunit), Interleukin 1 receptor,
type II (Ligand‐binding subunit) |
IL‐18 receptor accessory
protein (Other subunit), Interleukin‐18 1
(Ligand‐binding subunit) |
| Inhibitors |
anakinra
(pK
d 7.8) [44] |
– |
– |
– |
– |
| Endogenous agonists |
IL‐1α (IL1A, P01583),
IL‐1β (IL1B, P01584) |
IL‐33 (IL33, O95760) |
IL‐36α (IL36A, Q9UHA7),
IL‐36β (IL36B, Q9NZH7),
IL‐36γ (IL36G, Q9NZH8) |
– |
IL‐18 (IL18, Q14116),
IL‐37 (IL37, Q9NZH6) |
| Endogenous antagonists |
IL‐1 receptor
antagonist (IL1RN, P18510) |
– |
IL‐36 receptor
antagonist (IL36RN, Q9UBH0) |
– |
– |
| Selective antagonists |
AF12198
[3] |
– |
– |
– |
– |
| Comments |
– |
– |
IL‐36 receptor
antagonist (IL36RN, Q9UBH0) is a
highly specific antagonist of the response to IL‐36γ (IL36G, Q9NZH8). |
Decoy receptor that binds
IL‐1α (IL1A, P01583),
IL‐1β (IL1B, P01584) and
IL‐1 receptor
antagonist (IL1RN, P18510). |
– |
