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. 2015 Dec 9;172(24):5979–6023. doi: 10.1111/bph.13353
Nomenclature neurotrophic tyrosine kinase, receptor, type 1 neurotrophic tyrosine kinase, receptor, type 2 neurotrophic tyrosine kinase, receptor, type 3
Common abreviation trkA trkB trkC
HGNC, UniProt NTRK1, P04629 NTRK2, Q16620 NTRK3, Q16288
EC number 2.7.10.1 2.7.10.1 2.7.10.1
Endogenous ligands NGF (NGF, P01138) >neurotrophin‐3 (NTF3, P20783) BDNF (BDNF, P23560), neurotrophin‐4 (NTF4, P34130) >neurotrophin‐3 (NTF3, P20783)
Endogenous ligands neurotrophin‐3 (NTF3, P20783)
Inhibitors compound 2c [PMID: 24900538] (pIC50 8.9) [189], milciclib (pIC50 7.3) [17]
(Sub)family‐selective inhibitors AZD1332 (pIC50>8.3) 9, GNF‐5837 (pIC50 8) [5] AZD1332 (pIC50>8.3) 9, GNF‐5837 (pIC50 8.1) [5] AZD1332 (pIC50>8.3) 9, GNF‐5837 (pIC50 8.1) [5]