Nomenclature | neurotrophic tyrosine kinase, receptor, type 1 | neurotrophic tyrosine kinase, receptor, type 2 | neurotrophic tyrosine kinase, receptor, type 3 |
Common abreviation | trkA | trkB | trkC |
HGNC, UniProt | NTRK1, P04629 | NTRK2, Q16620 | NTRK3, Q16288 |
EC number | 2.7.10.1 | 2.7.10.1 | 2.7.10.1 |
Endogenous ligands | NGF (NGF, P01138) >neurotrophin‐3 (NTF3, P20783) | BDNF (BDNF, P23560), neurotrophin‐4 (NTF4, P34130) >neurotrophin‐3 (NTF3, P20783) | – |
Endogenous ligands | – | – | neurotrophin‐3 (NTF3, P20783) |
Inhibitors | compound 2c [PMID: 24900538] (pIC50 8.9) [189], milciclib (pIC50 7.3) [17] | – | – |
(Sub)family‐selective inhibitors | AZD1332 (pIC50>8.3) 9, GNF‐5837 (pIC50 8) [5] | AZD1332 (pIC50>8.3) 9, GNF‐5837 (pIC50 8.1) [5] | AZD1332 (pIC50>8.3) 9, GNF‐5837 (pIC50 8.1) [5] |