Nomenclature | PTH1 receptor | PTH2 receptor |
HGNC, UniProt | PTH1R, Q03431 | PTH2R, P49190 |
Rank order of potency | PTH (PTH, P01270) = PTHrP (PTHLH, P12272) | TIP39 (PTH2, Q96A98), PTH (PTH, P01270) ≫PTHrP (PTHLH, P12272) |
Endogenous agonists | – | TIP39 (PTH2, Q96A98) (pIC50 7.6–9.2) [626, 766] |
Agonists | teriparatide (pIC50 7.4) [573] | – |
Selective agonists | PTHrP‐(1‐34) (human) (pIC50 7.8–8.1) [574] – Rat | – |