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. 2015 Dec 9;172(24):5744–5869. doi: 10.1111/bph.13348
Nomenclature MAS1L MRGPRD MRGPRE MRGPRF MRGPRG
HGNC, UniProt MAS1L, P35410 MRGPRD, Q8TDS7 MRGPRE, Q86SM8 MRGPRF, Q96AM1 MRGPRG, Q86SM5
Endogenous agonists β‐alanine (pEC50 4.8) [1729, 1785]
Comments An endogenous peptide with a high degree of sequence similarity to angiotensin‐(1‐7) (AGT, P01019), alamandine (AGT), was shown to promote NO release in MRGPRD‐transfected cells. The binding of alamandine to MRGPRD to was shown to be blocked by D‐Pro7‐angiotensin‐(1‐7), β‐alanine and PD123319 [1045]. Genetic ablation of MRGPRD+ neurons of adult mice decreased behavioural sensitivity to mechanical stimuli but not to thermal stimuli [278]. See reviews [396] and [1779]. See reviews [396] and [1779]. MRGPRF has been reported to respond to stimulation by angiotensin metabolites [589]. See reviews [396] and [1779]. See reviews [396] and [1779].