Nomenclature | CCR6 | CCR7 | CCR8 | CCR9 | CCR10 |
HGNC, UniProt | CCR6, P51684 | CCR7, P32248 | CCR8, P51685 | CCR9, P51686 | CCR10, P46092 |
Endogenous agonists | CCL20 (CCL20, P78556) (pIC50 7.9–8.5) [18, 74, 1526], beta‐defensin 4A (DEFB4A DEFB4B, O15263) (Selective) [2081] | CCL21 (CCL21, O00585) (Selective) (pIC50 9.3) [2099], CCL19 (CCL19, Q99731) (Selective) (pIC50 7.7–9, median 8.6) [1449, 2098, 2099] | CCL1 (CCL1, P22362) (Selective) (pIC50 8.5–9.8) [387, 710, 824], CCL8 {Mouse} – Mouse | CCL25 (CCL25, O15444) (Selective) | CCL27 (CCL27, Q9Y4X3) (Selective), CCL28 (CCL28, Q9NRJ3) (Selective) |
Agonists | – | – | vMIP‐I (pIC50 8.9–9.9) [387, 824] | – | – |
Selective antagonists | – | – | vMCC‐I (pIC50 9.4) [387] | – | – |
Labelled ligands | [125I]CCL20 (human) (Agonist) (pK d∼10) [641] | [125I]CCL19 (human) (Agonist), [125I]CCL21 (human) (Agonist) [856] | [125I]CCL1 (human) (Agonist) (pK d 8.9–9.7) [824, 1597] | [125I]CCL25 (human) (Agonist) | – |