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. 2015 Dec 9;172(24):5744–5869. doi: 10.1111/bph.13348
Nomenclature CCR6 CCR7 CCR8 CCR9 CCR10
HGNC, UniProt CCR6, P51684 CCR7, P32248 CCR8, P51685 CCR9, P51686 CCR10, P46092
Endogenous agonists CCL20 (CCL20, P78556) (pIC50 7.9–8.5) [18, 74, 1526], beta‐defensin 4A (DEFB4A DEFB4B, O15263) (Selective) [2081] CCL21 (CCL21, O00585) (Selective) (pIC50 9.3) [2099], CCL19 (CCL19, Q99731) (Selective) (pIC50 7.7–9, median 8.6) [1449, 2098, 2099] CCL1 (CCL1, P22362) (Selective) (pIC50 8.5–9.8) [387, 710, 824], CCL8 {Mouse} – Mouse CCL25 (CCL25, O15444) (Selective) CCL27 (CCL27, Q9Y4X3) (Selective), CCL28 (CCL28, Q9NRJ3) (Selective)
Agonists vMIP‐I (pIC50 8.9–9.9) [387, 824]
Selective antagonists vMCC‐I (pIC50 9.4) [387]
Labelled ligands [125I]CCL20 (human) (Agonist) (pK d∼10) [641] [125I]CCL19 (human) (Agonist), [125I]CCL21 (human) (Agonist) [856] [125I]CCL1 (human) (Agonist) (pK d 8.9–9.7) [824, 1597] [125I]CCL25 (human) (Agonist)