| Nomenclature | CX3CR1 | XCR1 | ACKR1 | ACKR2 |
| HGNC, UniProt | CX3CR1, P49238 | XCR1, P46094 | ACKR1, Q16570 | ACKR2, O00590 |
| Endogenous ligands | – | – | CXCL5 (CXCL5, P42830), CXCL6 (CXCL6, P80162), CXCL8 (CXCL8, P10145), CXCL11 (CXCL11, O14625), CCL2 (CCL2, P13500), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL11 (CCL11, P51671), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583) | CCL2 (CCL2, P13500), CCL3 (CCL3, P10147), CCL4 (CCL4, P13236), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL8 (CCL8, P80075), CCL11 (CCL11, P51671), CCL13 (CCL13, Q99616), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583), CCL22 (CCL22, O00626) |
| Endogenous agonists | CX3CL1 (CX3CL1, P78423) (Selective) (pIC50 8.9) [577] | XCL1 (XCL1, P47992) (Selective), XCL2 (XCL2, Q9UBD3) (Selective) | – | – |
| Labelled ligands | [125I]CX3CL1 (human) (Agonist) | – | – | |
| Comments | – | When fused with secreted alkaline phophatase (SEAP), XCL1 functions as a probe at XCR1 | ACKR1 is used by Plasmodium vivax and Plasmodium knowlsei for entering erythrocytes. |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.