Nomenclature	GPR45	GPR50	GPR52	GPR61
HGNC, UniProt	GPR45, Q9Y5Y3	GPR50, Q13585	GPR52, Q9Y2T5	GPR61, Q9BZJ8
Comments	–	GPR50 is structurally related to MT1 and MT2 melatonin receptors, with which it heterodimerises constitutively and specifically [1089]. Gpr50 knockout mice display abnormal thermoregulation and are much more likely than wild‐type mice to enter fasting‐induced torpor [111].	First small molecule agonist reported [1703].	GPR61 deficient mice exhibit obesity associated with hyperphagia [1363]. Although no endogenous ligands have been identified, 5‐(nonyloxy)tryptamine has been reported to be a low affinity inverse agonist [1852].