| Nomenclature | HCA1 receptor | HCA2 receptor | HCA3 receptor |
| HGNC, UniProt | HCAR1, Q9BXC0 | HCAR2, Q8TDS4 | HCAR3, P49019 |
| Endogenous agonists | L‐lactic acid (Selective) (pEC50 1.3–2.9) [14, 256, 1124, 1785] | β‐D‐hydroxybutyric acid (pEC50 3.1) [1838] | 3‐hydroxyoctanoic acid (pEC50 5.1) [13] |
| Agonists | compound 2 [PMID: 24486398] (pEC50 7.2) [1630], 3,5‐dihydroxybenzoic acid (pEC50 3.7) [1121] | SCH 900271 (pEC50 8.7) [1454], GSK256073 (pEC50 7.5) [1790] | – |
| Selective agonists | – | MK 6892 (pEC50 7.8) [1719], MK 1903 (pEC50 7.6) [163], nicotinic acid (pEC50 6–7.2) [1774, 1913, 2036], acipimox (pEC50 5.2–5.6) [1774, 2036], monomethylfumarate (pEC50 5) [1859] | compound 6o [PMID: 19524438] (pEC50 8.5) [1751], IBC 293 (pEC50 6.4) [1697] |
| Labelled ligands | – | [3H]nicotinic acid (Agonist) (pK d 7–7.3) [1774, 1913, 2036] | – |
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