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. 2015 Dec 9;172(24):5744–5869. doi: 10.1111/bph.13348
Nomenclature MC1 receptor MC2 receptor MC3 receptor MC4 receptor MC5 receptor
HGNC, UniProt MC1R, Q01726 MC2R, Q01718 MC3R, P41968 MC4R, P32245 MC5R, P33032
Rank order of potency α‐MSH (POMC, P01189) >β‐MSH (POMC, P01189) >ACTH (POMC, P01189), γ‐MSH (POMC, P01189) ACTH (POMC, P01189) γ‐MSH (POMC, P01189), β‐MSH (POMC, P01189) >ACTH (POMC, P01189), α‐MSH (POMC, P01189) β‐MSH (POMC, P01189) >α‐MSH (POMC, P01189), ACTH (POMC, P01189) >γ‐MSH (POMC, P01189) α‐MSH (POMC, P01189) >β‐MSH (POMC, P01189) >ACTH (POMC, P01189) >γ‐MSH (POMC, P01189)
Selective agonists corticotropin zinchydroxide [D‐Trp8]γ‐MSH (pIC50 8.2) [645] THIQ (pIC50 8.9) [1690]
Antagonists PG‐106 (pIC50 6.7) [646]
Selective antagonists MBP10 (pIC50 10) [117], HS014 (pK i 8.5) [1667]
Labelled ligands [125I]NDP‐MSH (Agonist) (pK d 9.5) [991] [125I]ACTH‐(1‐24) (Agonist) [125I]NDP‐MSH (Agonist) (pK d 9.7) [991], [125I]SHU9119 (Antagonist) [1392] [125I]SHU9119 (Antagonist) (pK d 9.2) [1392], [125I]NDP‐MSH (Agonist) (pK d 8.4–8.9) [991, 1665] [125I]NDP‐MSH (Agonist) (pK d 8.6) [991]