Nomenclature	NPFF1 receptor	NPFF2 receptor
HGNC, UniProt	NPFFR1, Q9GZQ6	NPFFR2, Q9Y5X5
Rank order of potency	RFRP‐1 (NPVF, Q9HCQ7) >RFRP‐3 (NPVF, Q9HCQ7) > FMRFneuropeptide FF (NPFF, O15130) >neuropeptide AF (NPFF, O15130) >neuropeptide SF (NPFF, O15130), QRFP43 (QRFP, P83859), PrRP‐31 (PRLH, P81277) [628]	neuropeptide AF (NPFF, O15130), neuropeptide FF (NPFF, O15130) >PrRP‐31 (PRLH, P81277) > FMRF, QRFP43 (QRFP, P83859) >neuropeptide SF (NPFF, O15130) [628]
Endogenous agonists	neuropeptide FF (NPFF, O15130) (Selective) (pK i 8.5–9.9) [628, 629, 1306], RFRP‐3 (NPVF, Q9HCQ7) (Selective) (pK i 9.2–9.3) [629, 630, 1306]	neuropeptide FF (NPFF, O15130) (Selective) (pK i 9.7) [629, 1305]
Selective agonists	–	dNPA (pK i 10.6) [1607], AC263093 (pEC50 5.2–5.9) [1036]
Antagonists	RF9 (pK i 7.2) [1745]	–
Selective antagonists	AC262620 (pK i 7.7–8.1) [1036], AC262970 (pK i 7.4–8.1) [1036]	–
Labelled ligands	[125I]Y‐RFRP‐3 (Agonist) (pK d 9.7) [629], [3H]NPVF (Agonist) (pK d 8.6) [1855], [125I]NPFF (Agonist) [628]	[125I]EYF (Agonist) (pK d 10.2) [1306], [3H]EYF (Agonist) (pK d 9.3) [1855], [125I]NPFF (Agonist) [628]