Nomenclature | Retinoic acid receptor‐α | Retinoic acid receptor‐β | Retinoic acid receptor‐γ |
Systematic nomenclature | NR1B1 | NR1B2 | NR1B3 |
HGNC, UniProt | RARA, P10276 | RARB, P10826 | RARG, P13631 |
Agonists | tretinoin (pEC50 7.8) [26] | tretinoin (pEC50 7.9) [26] | tretinoin (pEC50 9.7) [26] |
(Sub)family‐selective agonists | tazarotene (pEC50 7.2) [26] | tazarotene (pEC50 9.1) [26], adapalene (pK i 7.5) [25] | tazarotene (pEC50 7.4) [26], adapalene (pK i 6.9) [25] |
Selective agonists | BMS753 (pK i 8.7) [53], Ro 40‐6055 (pK d 8.2) [33], tamibarotene (pIC50 6.9) [65, 108, 146] | AC261066 (pEC50 7.9–8.1) [90], AC55649 (pEC50 6.5–7.3) [90] | AHPN (pK i 7.1) [25] |
Selective antagonists | Ro 41‐5253 (pIC50 6.3–7.2) [2, 70] | – | MM 11253 [77] |