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. 2015 Dec 9;172(24):6110–6202. doi: 10.1111/bph.13355
Nomenclature Excitatory amino acid Excitatory amino acid Excitatory amino acid Excitatory amino acid Excitatory amino acid
transporter 1 transporter 2 transporter 3 transporter 4 transporter 5
Systematic nomenclature SLC1A3 SLC1A2 SLC1A1 SLC1A6 SLC1A7
Common abreviation EAAT1 EAAT2 EAAT3 EAAT4 EAAT5
HGNC, UniProt SLC1A3, P43003 SLC1A2, P43004 SLC1A1, P43005 SLC1A6, P48664 SLC1A7, O00341
Substrates DL‐threo‐β‐hydroxyaspartate (K i5.8 × 10−5M) [444], D‐aspartic acid, L‐trans‐2, 4‐pyrolidine dicarboxylate D‐aspartic acid, DL‐threo‐β‐hydroxyaspartate, L‐trans‐2, 4‐pyrolidine dicarboxylate [285] L‐trans‐2, 4‐pyrolidine dicarboxylate, DL‐threo‐β‐hydroxyaspartate, D‐aspartic acid D‐aspartic acid, DL‐threo‐β‐hydroxyaspartate, L‐trans‐2, 4‐pyrolidine dicarboxylate D‐aspartic acid, L‐trans‐2, 4‐pyrolidine dicarboxylate, DL‐threo‐β‐hydroxyaspartate
Endogenous substrates L‐aspartic acid, L‐glutamic acid L‐glutamic acid, L‐aspartic acid L‐aspartic acid, L‐cysteine [543], L‐glutamic acid L‐glutamic acid, L‐aspartic acid L‐aspartic acid, L‐glutamic acid
Stoichiometry Probably 3 Na+: 1 H+ : 1 glutamate (in): 1 K+ (out) 3 Na+: 1 H+ : 1 glutamate (in): 1 K+ (out) [311] 3 Na+: 1 H+ : 1 glutamate (in): 1 K+ (out) [542] Probably 3 Na+: 1 H+ : 1 glutamate (in): 1 K+(out) Probably 3 Na+: 1 H+ : 1 glutamate (in): 1 K+ (out)
Inhibitors UCPH‐101 (membrane potential assay) (pIC50 6.9) [252], DL‐TBOA (pK B 5) [444] WAY‐213613 (pIC50 7.1) [133], DL‐TBOA (pK B 6.9) [444], SYM2081 (pK B 5.5) [492], dihydrokainate (pK B 5), threo‐3‐methylglutamate (pK B 4.7) [492] NBI‐59159 (pIC50 7.1) [131], L‐β‐BA ([3H]D‐aspartate uptake assay) (pK i 6.1) [150], DL‐TBOA (pIC50 5.1) [446] DL‐TBOA (pK i 5.4) [443], threo‐3‐methylglutamate (pK i 4.3) [141] DL‐TBOA (pK i 5.5) [443]
Labelled ligands [3H]ETB‐TBOA (Binding) (pK d 7.8) [445] – Rat, [3H](2S,4R)‐4‐methylglutamate, [3H]D‐aspartic acid, [3H]L‐aspartic acid [3H]ETB‐TBOA (Binding) (pK d 7.8) [445] – Rat, [3H](2S,4R)‐4‐methylglutamate, [3H]D‐aspartic acid, [3H]L‐aspartic acid [3H]ETB‐TBOA (Binding) (pK d 6.5) [445] – Rat, [3H]D‐aspartic acid, [3H]L‐aspartic acid [3H]ETB‐TBOA (Binding) (pK d 7.9) [445] – Rat, [3H]D‐aspartic acid, [3H]L‐aspartic acid [3H]ETB‐TBOA (Binding) (pK d 7.6) [445] – Rat, [3H]D‐aspartic acid, [3H]L‐aspartic acid