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. 2015 Dec 9;172(24):6110–6202. doi: 10.1111/bph.13355
Nomenclature Sodium/glucose Sodium/glucose Low affinity sodium‐ Sodium/glucose Sodium/glucose
cotransporter 1 cotransporter 2 glucose cotransporter cotransporter 4 cotransporter 5
Systematic nomenclature SLC5A1 SLC5A2 SLC5A4 SLC5A9 SLC5A10
Common abreviation SGLT1 SGLT2 SGLT3 SGLT4 SGLT5
HGNC, UniProt SLC5A1, P13866 SLC5A2, P31639 SLC5A4, Q9NY91 SLC5A9, Q2M3M2 SLC5A10, A0PJK1
Substrates D‐galactose [501], α‐MDG [501], D‐glucose [501] α‐MDG, D‐glucose D‐glucose [501], 1‐deoxynojirimycin‐1‐sulfonic acid [501], N‐ethyl‐1‐deoxynojirimycin [501], miglustat [501], miglitol [501], 1‐deoxynojirimycin [501] D‐glucose, D‐mannose, α‐MDG D‐galactose, D‐glucose
Stoichiometry 2 Na+ : 1 glucose [266] 1 Na+ : 1 glucose [236]
Inhibitors sotagliflozin (pIC50 7.4) [538], dapagliflozin (pIC50 6.4) [313], canagliflozin (pIC50 6.2) [316], remogliflozin (pK i 5.3) [172], empagliflozin (pIC50 5.1) [204], sergliflozin (pK i 5.1) [272] empagliflozin (pIC50 8.5) [204], canagliflozin (pIC50 8.4) [316], remogliflozin (pK i 7.9) [172], sergliflozin (pK i 6.8) [272]
Selective inhibitors dapagliflozin (pIC50 9.3) [269]
Comments 'sodium/glucose cotransporter 3' is a misnomer since SGLT3 is a glucosensor.