Nomenclature | NIS | SMVT | SMCT1 | SMCT2 |
Systematic nomenclature | SLC5A5 | SLC5A6 | SLC5A8 | SLC5A12 |
HGNC, UniProt | SLC5A5, Q92911 | SLC5A6, Q9Y289 | SLC5A8, Q8N695 | SLC5A12, Q1EHB4 |
Substrates | ClO4‐, SCN‐, I‐, NO3 ‐, pertechnetate | lipoic acid [556], pantothenic acid [556], I‐ [556], biotin [556] | propanoic acid, 3‐bromopyruvate, pyroglutamic acid, nicotinic acid, D‐lactic acid, β‐D‐hydroxybutyric acid, L‐lactic acid, salicylic acid, dichloroacetate, butyric acid, α‐ketoisocaproate, pyruvic acid, acetoacetic acid, benzoate, γ‐hydroxybutyric acid, 2‐oxothiazolidine‐4‐carboxylate, acetic acid, β‐L‐hydroxybutyric acid, 5‐aminosalicylate | pyruvic acid, L‐lactic acid, nicotinic acid |
Stoichiometry | 2Na+ : 1 I‐ [149]; 1Na+ : 1 ClO4 ‐ [123] | 2Na+ : 1 biotin (or pantothenic acid) [390] | 2Na+ : 1 monocarboxylate [94] | – |
Inhibitors | – | – | fenoprofen (pIC50 4.6) [248], ibuprofen (pIC50 4.2) [248], ketoprofen (pIC50 3.9) [248] | – |