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. 2015 Dec 9;172(24):6110–6202. doi: 10.1111/bph.13355
Nomenclature NIS SMVT SMCT1 SMCT2
Systematic nomenclature SLC5A5 SLC5A6 SLC5A8 SLC5A12
HGNC, UniProt SLC5A5, Q92911 SLC5A6, Q9Y289 SLC5A8, Q8N695 SLC5A12, Q1EHB4
Substrates ClO4, SCN, I, NO3 , pertechnetate lipoic acid [556], pantothenic acid [556], I [556], biotin [556] propanoic acid, 3‐bromopyruvate, pyroglutamic acid, nicotinic acid, D‐lactic acid, β‐D‐hydroxybutyric acid, L‐lactic acid, salicylic acid, dichloroacetate, butyric acid, α‐ketoisocaproate, pyruvic acid, acetoacetic acid, benzoate, γ‐hydroxybutyric acid, 2‐oxothiazolidine‐4‐carboxylate, acetic acid, β‐L‐hydroxybutyric acid, 5‐aminosalicylate pyruvic acid, L‐lactic acid, nicotinic acid
Stoichiometry 2Na+ : 1 I [149]; 1Na+ : 1 ClO4 [123] 2Na+ : 1 biotin (or pantothenic acid) [390] 2Na+ : 1 monocarboxylate [94]
Inhibitors fenoprofen (pIC50 4.6) [248], ibuprofen (pIC50 4.2) [248], ketoprofen (pIC50 3.9) [248]