Nomenclature | BGT1 | TauT | CT1 |
Systematic nomenclature | SLC6A12 | SLC6A6 | SLC6A8 |
HGNC, UniProt | SLC6A12, P48065 | SLC6A6, P31641 | SLC6A8, P48029 |
Endogenous substrates | GABA, betaine | β‐alanine, taurine, GABA [9] | creatine |
Stoichiometry | 3Na+: 1 (or 2) Cl‐: 1GABA | 2Na+: 1Cl‐: 1 taurine | Probably 2Na+: 1Cl‐: 1 creatine |
Selective inhibitors | NNC052090 (pK i 5.9) [473] – Mouse, (R/S) EF‐1500 (pIC50 4.9), (R)‐EF‐1520 (pIC50 3.7–4.7), (S)‐EF‐1520 (pIC50 3.6–4.5), LU32‐176B (pIC50 4) [512] – Mouse | – | – |