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. 2015 Dec 9;172(24):6110–6202. doi: 10.1111/bph.13355
Nomenclature Sodium‐dependent vitamin C Sodium‐dependent vitamin C Sodium‐dependent vitamin C Sodium‐dependent nucleobase
transporter 1 transporter 2 transporter 3 transporter
Systematic nomenclature SLC23A1 SLC23A2 SLC23A3 SLC23A4
Common abreviation SVCT1 SVCT2 SVCT3 SNBT1
HGNC, UniProt SLC23A1, Q9UHI7 SLC23A2, Q9UGH3 SLC23A3, Q6PIS1 SLC23A4P, –
Endogenous substrates L‐ascorbic acid>D‐ascorbic acid>dehydroascorbic acid [483] L‐ascorbic acid>D‐ascorbic acid>dehydroascorbic acid [483] uracil>thymine>guanine, hypoxanthine>xanthine, uridine [526]
Substrates 5‐fluorouracil [526]
Stoichiometry 2 Na+: 1 ascorbic acid (in) [483] 2 Na+: 1 ascorbic acid (in) [483] 1 Na+ : 1 uracil (in) [526]
Inhibitors phloretin (pK i 4.2) [483]
Labelled ligands [14C]ascorbic acid (Binding) [326] [14C]ascorbic acid
Comments SLC23A3 does not transport ascorbic acid and remains an orphan transporter. SLC23A4/SNBT1 is found in rodents and non‐human primates, but the sequence is truncated in the human genome and named as a pseudogene, SLC23A4P