Nomenclature | Sodium‐dependent vitamin C | Sodium‐dependent vitamin C | Sodium‐dependent vitamin C | Sodium‐dependent nucleobase |
transporter 1 | transporter 2 | transporter 3 | transporter | |
Systematic nomenclature | SLC23A1 | SLC23A2 | SLC23A3 | SLC23A4 |
Common abreviation | SVCT1 | SVCT2 | SVCT3 | SNBT1 |
HGNC, UniProt | SLC23A1, Q9UHI7 | SLC23A2, Q9UGH3 | SLC23A3, Q6PIS1 | SLC23A4P, – |
Endogenous substrates | L‐ascorbic acid>D‐ascorbic acid>dehydroascorbic acid [483] | L‐ascorbic acid>D‐ascorbic acid>dehydroascorbic acid [483] | – | uracil>thymine>guanine, hypoxanthine>xanthine, uridine [526] |
Substrates | – | – | – | 5‐fluorouracil [526] |
Stoichiometry | 2 Na+: 1 ascorbic acid (in) [483] | 2 Na+: 1 ascorbic acid (in) [483] | – | 1 Na+ : 1 uracil (in) [526] |
Inhibitors | phloretin (pK i 4.2) [483] | – | – | – |
Labelled ligands | [14C]ascorbic acid (Binding) [326] | [14C]ascorbic acid | – | – |
Comments | – | – | SLC23A3 does not transport ascorbic acid and remains an orphan transporter. | SLC23A4/SNBT1 is found in rodents and non‐human primates, but the sequence is truncated in the human genome and named as a pseudogene, SLC23A4P |