Nomenclature |
Proton‐coupled Amino
acid
|
Proton‐coupled Amino
acid
|
Proton‐coupled Amino
acid
|
Proton‐coupled Amino
acid
|
|
Transporter 1
|
Transporter 2
|
Transporter 3
|
Transporter 4
|
Systematic nomenclature |
SLC36A1 |
SLC36A2 |
SLC36A3 |
SLC36A4 |
Common abreviation |
PAT1 |
PAT2 |
PAT3 |
PAT4 |
HGNC, UniProt |
SLC36A1,
Q7Z2H8
|
SLC36A2,
Q495M3
|
SLC36A3,
Q495N2
|
SLC36A4,
Q6YBV0
|
Substrates |
MeAIB [86], betaine,
vigabatrin
[1], 5‐aminolevulinic
acid, β‐guanidinopropionic acid, gaboxadol
[299], L‐azetidine‐2‐carboxylate [274], THPO [300] |
MeAIB [87], L‐azetidine‐2‐carboxylate [274] |
– |
– |
Endogenous substrates |
GABA, L‐alanine,
β‐alanine, taurine,
D‐cysteine,
D‐serine,
L‐proline,
D‐proline,
trans‐4‐hydroxy‐proline [338], glycine
[338], D‐alanine,
sarcosine
|
L‐alanine,
β‐alanine, glycine,
sarcosine,
L‐proline,
trans‐4‐hydroxy‐proline
|
– |
L‐tryptophan
[384], L‐proline
[384] |
Stoichiometry |
1 H+ : 1 amino acid
(in) |
1 H+ : 1 amino acid
(in) |
Unknown |
Unknown |
Inhibitors |
5‐hydroxy‐L‐tryptophan (pK
i 3) [339], L‐tryptophan
(pK
i 2.3) [339], indole‐3‐propionic
acid (pK
i 2.3) [339], 5‐hydroxytryptamine (pK
i 2.2) [339] |
5‐hydroxy‐L‐tryptophan (pIC50 2.8)
[137], α‐methyl‐D,L‐tryptophan
(pIC50 2.5) [137] |
– |
– |
Comments |
[3H] or
[14C] labelled substrates as listed above are used as
probes |
[3H] or
[14C] labelled substrates as listed above are used as
probes |
– |
– |