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. 2015 Dec 9;172(24):6110–6202. doi: 10.1111/bph.13355
Nomenclature Proton‐coupled Amino acid Proton‐coupled Amino acid Proton‐coupled Amino acid Proton‐coupled Amino acid
Transporter 1 Transporter 2 Transporter 3 Transporter 4
Systematic nomenclature SLC36A1 SLC36A2 SLC36A3 SLC36A4
Common abreviation PAT1 PAT2 PAT3 PAT4
HGNC, UniProt SLC36A1, Q7Z2H8 SLC36A2, Q495M3 SLC36A3, Q495N2 SLC36A4, Q6YBV0
Substrates MeAIB [86], betaine, vigabatrin [1], 5‐aminolevulinic acid, β‐guanidinopropionic acid, gaboxadol [299], L‐azetidine‐2‐carboxylate [274], THPO [300] MeAIB [87], L‐azetidine‐2‐carboxylate [274]
Endogenous substrates GABA, L‐alanine, β‐alanine, taurine, D‐cysteine, D‐serine, L‐proline, D‐proline, trans‐4‐hydroxy‐proline [338], glycine [338], D‐alanine, sarcosine L‐alanine, β‐alanine, glycine, sarcosine, L‐proline, trans‐4‐hydroxy‐proline L‐tryptophan [384], L‐proline [384]
Stoichiometry 1 H+ : 1 amino acid (in) 1 H+ : 1 amino acid (in) Unknown Unknown
Inhibitors 5‐hydroxy‐L‐tryptophan (pK i 3) [339], L‐tryptophan (pK i 2.3) [339], indole‐3‐propionic acid (pK i 2.3) [339], 5‐hydroxytryptamine (pK i 2.2) [339] 5‐hydroxy‐L‐tryptophan (pIC50 2.8) [137], α‐methyl‐D,L‐tryptophan (pIC50 2.5) [137]
Comments [3H] or [14C] labelled substrates as listed above are used as probes [3H] or [14C] labelled substrates as listed above are used as probes