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. 2015 Dec 9;172(24):6110–6202. doi: 10.1111/bph.13355
Nomenclature ABCG1 ABCG2 ABCG4 ABCG5 ABCG8
Common abreviation ABC8 ABCP
HGNC, UniProt ABCG1, P45844 ABCG2, Q9UNQ0 ABCG4, Q9H172 ABCG5, Q9H222 ABCG8, Q9H221
Comments Transports sterols and choline phospholipids [275] Exhibits a broad substrate specificity, including urate and haem, as well as multiple synthetic compounds [275]. The functional transporter is likely to be a homodimer, although higher oligomeric states have also been proposed. Putative functional dependence on ABCG1 Transports phytosterols and cholesterol; forms an obligate heterodimer with ABCG8. Loss‐of‐function mutations in ABCG5 are associated with sitosterolemia (OMIM: 210250). Transports phytosterols and cholesterol; forms an obligate heterodimer with ABCG5. Loss‐of‐function mutations in ABCG8 are associated with sitosterolemia (OMIM: 210250).