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. 2013 Sep;54(3):138–145.

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© Copyright by Pacini Editore SpA, Pisa, Italy

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. For details, please refer to http://creativecommons.org/licenses/by-nc-nd/3.0/

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Fig. 1. — Osteonecrosis of the jaw as induced by BPNs in an edentulous patient. Is reported an example of 80-year-old woman diagnosed with multiple myeloma was on long-term treatment with biphosphonates before developing ONJ in relation with dental extractions. (A) Sagittal view of the patient's profile. (B) Macroscopic appearance of oral osteonecrosis of the jaw. It can be seen that: 1) granulation tissue delimiting inflammation areas; 2) purulent exudate; 3) exposed osteonecrotic areas. (C) Bone loss in jaw is evident in particular in the lower right part of the Figure (panoramic x-Ray).