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The active-site region of the C. roseus iridoid synthase from the IRIS+NAD++10-oxogeranial structure (PDB^^ID: 5DBI). A) Electron-density map of bound NAD+ and substrate 10-oxogeranial (2 Fo-Fc map contoured at 1 sigma). B) Interaction of active-site residues K146 and Y178 with NAD+ and 10-oxogeranial substrates. The C4-C5 rotation to enable cyclization is indicated. Dashed lines indicate distances of interest. C) Progesterone modeled into the IRIS active site.
