Table 4. Targets with significantly lower docking Z’-scores towards sunitinib than sorafenib.
| PDB ID | Putative Target | Sunitinib Z'-Score | Sorafenib Z'-Score | Difference | P-value |
|---|---|---|---|---|---|
| 1XAP | Retinoic acid receptor beta | -0.237588 | 2.74816 | -2.985748 | 0.0041 |
| 1MVC | Retinoic acid receptor RXR-alpha | -0.171023 | 1.83455 | -2.005573 | 0.0293 |
| 1EXX | Retinoic acid receptor gamma | 0.883029 | 2.81209 | -1.929061 | 0.0324 |
| 1RFN | Coagulation factor IX | 0.309693 | 2.16421 | -1.854517 | 0.0383 |
| 1Z6J | Coagulation factor VII | -0.867828 | 0.979206 | -1.847034 | 0.0388 |
| 1FBY | Retinoic acid receptor RXR-alpha | -0.0783559 | 1.6608 | -1.7391559 | 0.0478 |