Table 2. Correlations between mitochondrial tumor suppressor genes (SIRT3, SIRT4, MTUS1), mitochondrial DNA repair gene (OGG1-2a), proliferation marker (Ki-67) expression and clinicopathological characteristics of primary HNSCC†.
| T stage | C stage | N stage | M stage | Grade | Survival | SIRT3 | SIRT4 | MTUS1 | OGG1-2a | Ki-67 |
|---|---|---|---|---|---|---|---|---|---|---|
| T stage | 0.665*** | 0.501*** | 0.078 | 0.222* | -0.006 | 0.11 | -0.074 | 0.127 | 0.005 | 0.059 |
| C stage | 0.387*** | 0.053 | 0.204* | 0.021 | 0.138 | -0.1 | 0.085 | 0.048 | 0.053 | |
| N stage | 0.380*** | 0.037 | -0.051 | -0.226** | -0.261*** | -0.214* | -0.378*** | 0.078 | ||
| M stage. | 0.125 | 0.01 | -0.30*** | -0.185* | -0.289*** | -0.216* | 0.24** | |||
| Grade | 0.154 | 0.007 | -0.15 | 0.105 | 0.012 | 0.094 | ||||
| Survival | 0.15 | 0.05 | 0.08 | -0.083 | 0.100 | |||||
| SIRT3 | 0.523*** | 0.273*** | 0.213* | -0.054 | ||||||
| SIRT4 | 0.08 | 0.338*** | -0.108 | |||||||
| MTUS1 | 0.125* | -0.674*** | ||||||||
| OGG1-2a | 0.224* | |||||||||
| Ki-67 |
† Spearman Correlation Coefficients. The expression levels of SIRT3, SIRT4, MTUS1, OGG1-2a and Ki-67 for Patient Cohort were based on the relative mRNA level.
* p < 0.05
** p < 0.01 and
*** p < 0.001. The p values were computed using one way ANOVA and χ2-test.