KSR2 |
2Y4I |
Homo sapiens |
ATP + Mg |
MEK1 |
Unknown |
1 cation |
Active, phosphorylates MEK1 [4] |
HER3 |
4OTW |
H. sapiens |
Bosutinib |
– |
10−6 M [5] |
1 cation |
Active, autophosphorylates its own intracellular region, when immobilized on vesicles [5] |
|
4RIW |
H. sapiens |
AMP-PNP + Mg |
EGFR KD (V624R, F973A, L977A) |
|
|
|
|
4RIX (Q709R) |
H. sapiens |
AMP-PNP + Mg |
EGFR KD (V624R, F973A, L977A) |
|
|
|
|
4RIY (E909G) |
H. sapiens |
AMP-PNP + Mg |
EGFR KD (V624R, F973A, L977A) |
|
|
|
|
3KEX |
H. sapiens |
AMP-PNP + Mg |
– |
|
|
|
|
3LMG |
H. sapiens |
AMP-PNP + Mg |
– |
|
|
|
TYK2 JH2 |
3ZON |
H. sapiens |
IKK1 |
– |
10−5 M [37] |
1 cation |
Inactive [37] |
|
4WOV |
H. sapiens |
BMS-066 |
– |
|
|
|
|
4OLI |
H. sapiens |
Inhibitor 7012 |
JH2-JH1 (D1023N) |
|
|
|
|
5C03 |
H. sapiens |
ATPγS + Mg |
– |
|
|
|
|
5C01 |
H. sapiens |
Pyrazine inhibitor |
– |
|
|
|
JAK2 JH2 |
4FVP* |
H. sapiens |
– |
– |
10−6 M [6,45] |
1 cation |
Active, autophosphorylates on S523 and Y570 [6] |
|
4FVQ* |
H. sapiens |
ATP + Mg |
– |
|
|
|
|
4FVR (V617F)* |
H. sapiens |
ATP + Mg |
– |
|
|
|
JAK1 JH2 |
4L00 |
H. sapiens |
– |
– |
10−6 M [45] |
1 cation†
|
Inactive [65] |
|
4L01 (V658F) |
H. sapiens |
– |
– |
|
|
|
MLKL |
4BTF |
Mus musculus |
– |
– |
10−5 M (TSA) [26] |
No cation† [9,25,26] |
Inactive [25] |
|
4MWI |
H. sapiens |
– |
– |
|
|
|
|
4M67 |
H. sapiens |
– |
– |
|
|
|
|
4M68 |
M. musculus |
– |
– |
|
|
|
|
4M69 |
M. musculus |
– |
RIP3 KD |
|
|
|
STRADα |
3GNI |
H. sapiens |
ATP |
MO25 |
10−4–10−6 M [39,82] |
No cation [9] |
Inactive [140] |
|
2WTK |
H. sapiens |
AMP-PNP |
MO25 + LKB1 |
|
|
|
VRK3 |
2JII |
H. sapiens |
– |
– |
None |
N/A |
Inactive |
ILK |
3KMW |
H. sapiens |
ATP + Mg |
α-Parvin |
10−6 M [34] |
1 cation |
Inactive [34,40] |
|
3KMU |
H. sapiens |
– |
α-Parvin |
|
|
|
|
3REP |
H. sapiens |
ATP + Mn |
α-Parvin |
|
|
|
CASK |
3C0G |
H. sapiens |
3′-AMP |
– |
10−3 M [7,9] |
No cation |
Active, cations inhibit binding and activity. [7,24,83] |
|
3C0I |
H. sapiens |
3′-AMP |
– |
|
|
|
|
3C0H |
H. sapiens |
AMP-PNP (only AMP visible) |
– |
|
|
|
|
3TAC |
H. sapiens |
– |
Liprin-α2 |
|
|
|
|
3MFS (4M)‡
|
H. sapiens |
AMP-PNP |
– |
|
|
|
|
3MFU (4M)‡
|
H. sapiens |
AMP-PNP + Mn |
– |
|
|
|
|
3MFT (4M)‡
|
H. sapiens |
– |
– |
|
|
|
|
3MFR (4M)‡
|
H. sapiens |
– |
– |
|
|
|
ROR2 |
3ZZW |
H. sapiens |
– |
– |
None [55] |
N/A |
Inactive [55,102] |
|
4GT4 |
H. sapiens |
– |
– |
|
|
|
BIR2 |
4L68 |
Arabidopsis thaliana |
– |
– |
None [94] |
N/A |
Inactive [94] |
BSK8 |
4I92 |
A. thaliana |
– |
– |
Unknown |
1 cation |
Inactive [76] |
|
4I93 |
A. thaliana |
– |
– |
|
|
|
|
4I94 |
A. thaliana |
AMP-PNP |
– |
|
|
|
Titin |
4JNW |
H. sapiens |
– |
– |
10−4 M [113] |
Unknown |
Disputed [112–114] |
|
1TKI |
H. sapiens |
– |
– |
|
|
|
PAN3 |
4CYI |
Chaetomium thermophilum |
ATP + Mg |
– |
Unknown, but probably rather high affinity [78] |
1 cation |
Unknown, physiological role of PKD is to shuttle polyribonucleotides to PAN2 [81] |
|
4CYJ |
C. thermophilum |
ATP + Mg |
PAN2 |
|
|
|
|
4CZY |
Neurospora crassa |
AMP-PNP + Mg |
PAN2 |
|
|
|
|
4BWK |
N. crassa |
ATPγS |
– |
|
|
|
|
4BWX§
|
N. crassa |
ATPγS + Mg |
|
|
|
|
|
4BWP |
Drosophila melanogaster |
AMP-PN |
– |
|
|
|
|
4XR7 |
Saccharomyces cerevisiae |
– |
PAN2 |
|
|
|
ROP2 |
2W1Z |
T. gondii |
– |
– |
None [43] |
N/A |
Inactive [43] |
|
3DZO¶
|
T. gondii |
Mg |
– |
|
|
|
ROP5B |
3Q5Z |
T. gondii |
– |
– |
Unknown |
2 cations |
Inactive [110] |
|
3Q60 |
T. gondii |
ATP + Mg |
– |
|
|
|
|
4LV5 |
T. gondii |
ADP |
IRGa6 (M. musculus) |
|
|
|
ROP5C |
4LV8 |
T. gondii |
ADP + Mg |
IRGa6 (M. musculus) |
Unknown |
1 cation |
Unknown |
ROP8 |
3BYV |
T. gondii |
Mg |
– |
Unknown |
Unknown |
Unknown |
RNase L |
4O1O |
Sus scrofa |
– |
2-5A |
10−3 M [53] |
2 cations |
Inactive [52–54] |
|
4O1P |
S. scrofa |
AMP-PNP + Mg |
2-5A |
|
|
|
|
4OAU |
H. sapiens |
ADP + Mg |
2-5A |
|
|
|
|
4OAV |
H. sapiens |
AMP-PCP + Mg |
RNA + pUp |
|
|
|
WNK1 |
4Q2A |
Rattus norvegicus |
Br |
– |
Unknown |
Unknown |
Active [124] |
|
3FPQ |
R. norvegicus |
– |
– |
|
|
|
|
4PWN |
H. sapiens |
– |
– |
|
|
|
MviN |
3OTV |
Mycobacterium tuberculosis |
– |
– |
None [47] |
Unknown |
Inactive [47] |
|
3OUK |
M. tuberculosis |
– |
– |
|
|
|
|
3OUN |
M. tuberculosis |
– |
FhaA |
|
|
|
|
3UQC |
M. tuberculosis |
– |
– |
|
|
|
ADCK3 |
4PED |
H. sapiens |
– |
– |
Binds preferentially ADP [108] |
Unknown |
Inactive, can be activated with a single Gly-rich loop mutation [108] |