Table 1. The scope of included studies (n = 227).
| Original review n (%) | Updated review n (%) | Combined n (%) | |
|---|---|---|---|
| Study aims | |||
| Specifically considered outcome selection and measurement | 97 (49) | 22 (76) | 119 (52%) |
| Considered outcomes while addressing wider clinical trial design issues | 101 (51) | 7 (24) | 108 (48%) |
| Intended use of recommendations | |||
| Clinical trials | 141 (71) | 19 (66) | 160 (71) |
| Clinical research | 27 (14) | 4 (14) | 31 (14) |
| Clinical research and practice | 11 (6) | 4 (14) | 15 (7) |
| Clinical trials and clinical practice | 10 (5) | 0 (0) | 10 (4) |
| Clinical trials and regulatory purposes | 3 (2) | 0 (0) | 3 (1) |
| Trials and observational studies | 3 (2) | 0 (0) | 3 (1) |
| Clinical trial extension studies | 1 (4) | 1 (<1) | |
| Clinical trials, research and clinical record keeping | 1 (4) | 1 (<1) | |
| Observational studies | 1 (<1) | 0 (0) | 1 (<1) |
| Trials and case series | 1 (<1) | 0 (0) | 1 (<1) |
| Clinical research, clinical practice and regulatory purpose | 1 (<1) | 0 (0) | 1 (<1) |
| Population characteristics | |||
| Adults | 10 (5) | 11 (38) | 21 (9) |
| Children | 23 (12) | 2 (7) | 25 (11) |
| Adults and children | 13 (7) | 1 (4) | 14 (6) |
| Older adults | 3 (2) | 1 (4) | 4 (2) |
| Adults and neonates | 0 (0) | 1 (4) | 1 (<1) |
| Not specified | 149 (75) | 13 (45) | 162 (71) |
| Intervention characteristics | |||
| All intervention types | 7 (4) | 9 (31) | 16 (7) |
| Drug treatments | 40 (20) | 4 (14) | 44 (19) |
| Surgery | 13 (7) | 4 (14) | 17 (8) |
| Surgery only | 13 | 2 | |
| Surgery and compression therapy | 0 | 1 | |
| Surgery and injection | 0 | 1 | |
| Vaccine | 2 (1) | 0 (0) | 2 (1) |
| Rehabilitation | 1 (1) | 1 (4) | 2 (1) |
| Exercise | 1 (1) | 1 (4) | 2 (1) |
| Exercise (physical activity) | 1 | 0 | |
| Exercise (yoga) | 0 | 1 | |
| Procedure* | 5 (3) | 0 (0) | 5 (2) |
| Device** | 3 (2) | 0 (0) | 3 (1) |
| Other*** | 11 (6) | 5 (17) | 16 (7) |
| Not specified | 115 (58) | 5 (17) | 120 (53) |
*Procedure descriptions–
Procedure—Uterine artery embolization.
Procedure—Aortic valve stenosis (AS)—transcatheter aortic valve implantation.
Procedure—Aortic valve stenosis (AS).
Procedure—pulp treatments of primary teeth.
Procedure—drug-eluting coronary stents (DES).
**Device descriptions–
Device–Compression (n = 2).
Device—Mechanical circulatory support (MCS).
***Other descriptions–
Coronary angiogenesis.
Hip protectors.
Neuro-protective therapy (aka Neuroprotection).
Non-surgical treatment (no other detail given).
Operative and non-operative management.
Oral care products.
Ascorbic acid.
Fall injury prevention interventions.
Behavioural therapies or other kinds of nonpharmacologic therapies.
Psychological & behavioural: Psychosocial.
Maternity care.
Complementary and alternative medicine (CAM).
Chemotherapy.
Platelet transfusion trials.
Endovascular therapy.
Constraint-induced movement therapy (CIMT).