Table 1.
Examples of multi-targeting chalcones and potential relevance to their diverse bioactivities.
| Compound | Potential direct target | Potential bioactivity relevance |
|---|---|---|
| Isoliquiritigenin | EGFR | Anticancer |
| tyrosinase | Anti-pigmentation | |
| ALR2 | Anti-diabetic, Anti-inflammation | |
| BACE1 | Anti-AD | |
| ER | Growth Promotion | |
| GABAA receptor | Anxiolytic/Sedative | |
| H2 receptor | Gastric Protection | |
| α7-nAChR | Analgesic, Cognitive Enhancing | |
| Butein | IKKβ | Anticancer, Anti-inflammation |
| EGFR | Anticancer | |
| tyrosinase | Anti-pigmentation | |
| aromatase | Anticancer | |
| ALR2 | Anti-diabetic, Anti-inflammation | |
| HDAC | Anticancer | |
| Xanthohumol | IKKβ | Anticancer, Anti-inflammation |
| COX | Anti-inflammation | |
| aromatase | Anticancer | |
| α-glucosidase | Anti-diabetic | |
| CETP | Anti-dyslipidemia | |
| Licochalcone A | IKKβ | Anticancer, Anti-inflammation |
| PI3K, B-Raf, MEK1 | Anti-inflammation | |
| PTP1B | Anti-diabetic | |
| Broussochalcone A | PKC | Anti-inflammation |
| COX | Anti-inflammation | |
| PTP1B | Anti-diabetic | |
| Kuraridin | ALR2 | Anti-diabetic, Anti-inflammation |
| α-glucosidase | Anti-diabetic | |
| Xanthoangelol | Aurora kinases | Anticancer |
| EGFR | Anticancer |