Extended Data Figure 10. cis mAb treatment effectively restores risk-taking behavior and prevents tauopathy development and spread as well as brain atrophy after TBI.

a-c, cis mAb treatment effectively restores risk-taking behavior 2 months after ssTBI. Video-tracking data of each of all mice shows that ssTBI mice treated with cis mAb (n=7) spent similar and very little time in the open arm compared to sham mice (n=4), but much less time than TBI mice treated with IgG2b (n=7) (a). cis mAb-treated ssTBI mice had similar performance to sham in traveling velocity, but IgG2b-treated ssTBI mice traveled a greater velocity in the open arm (b). All three groups traveled similar total distance (c). Results are expressed as mean ± S.E.M. and p values determined using the Student's t test. d-f, cis mAb treatment effectively prevents tauopathy development and spread as well as brain atrophy 6 months after ssTBI. ssTBI mice were treated with cis mAb or IgG control for 2 weeks or 6 months, with sham mice as controls, followed by IF with various tauopathy epitopes (d), with immunostaining fluorescence intensity in the cortex and hippocampus being quantified (e), or to NeuN immunostaining for determining the thickness of the cortex and white matter at 6 months after TBI (f). n=4.