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. Author manuscript; available in PMC: 2016 Jan 23.
Published in final edited form as: Nature. 2015 Jul 15;523(7561):431–436. doi: 10.1038/nature14658

Table 1.

Binding affinities of cis and trans mAbs.

mAb Peptide Ka (Ms−1) Kd (s−1) Kd (nM)
cis pT231-tau 40,700 1.10×10−5 0.27
cis T231-tau 0.17 1.00×10−5 58,820
trans pT231-tau 250 1.05×10−5 42.0
trans T231-tau 4.5 1.95×10−5 4,333

The association rate constant (Ka), dissociation rate constant (Kd), and binding constant (Kd) of cis and trans mAbs toward pT231- or T231-tau peptide were determined by Biacore analysis. Ms−1, millisecond; M, molar; s, second.