Table 2.
Multivariable Associations of Three Treatments with Next Day Delirium, N=93a
| Un-weighted Outcome (not adjusted for time dependent confounding) | Weighted Outcomeb (adjusted for time dependent confounding) | |
|---|---|---|
| Variables with Time Dependent Confounding c | Odds Ratio (95% CI) d, e | Odds Ratio (95% CI) d, e |
| Cumulative dose of haloperidol (mg) among non-intubated patients | 1.06 (1.01 – 1.14) | 1.05 (1. 02 – 1.09) |
| Cumulative dose of haloperidol (mg) among intubated patients | 3.39 (1.61 – 8.01) | 5.48 (2.44 – 12.50) |
| Intubation | 3.38 (1.67 – 7.08) | 5.66 (2.70 – 12.02) |
| Cumulative dose of fentanyl (mg) | 1.03 (0.98 – 1.09) | 1.02 (0.95 – 1.12) |
Abbreviations: CI: credible interval (Bayesian equivalent of confidence interval), GCS: Glasgow Coma Scale, mg: milligrams, iqcodeA: informative questionnaire on cognitive decline in the elderly.
The 93 participants contributed 598 patient-days of follow-up.
Marginal structural model with weighting for cumulative fentanyl, cumulative haloperidol, and daily intubation. Model weight was product of individually standardized weights.
Each variable with time dependent confounding measured on day preceding diagnosis of delirium.
Significance defined as credible interval exclusive of 1.00.
All Odds Ratios include adjustment for age, APACHE II score, cognitive impairment defined as IQcode score > 3.3, nonwhite race, and patient weight.